Immune selection during chronic hepadnavirus infection
نویسندگان
چکیده
منابع مشابه
Selection of escape mutants from immune recognition during HIV infection.
We present computer simulations of the HIV infection based ona sophisticated cellular automata model of the immune response. The infection progresses following the well-known three-phase dynamics observed in patients, that is, acute, silent and acquired immunodeficiency.Antigenic shift and selection of escape viral mutants with low transcription rate explain the long term course of the asymptom...
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BACKGROUND & AIMS Current hepatitis B virus (HBV) management is challenging as treatment with nucleos(t)ide analogues needs to be maintained indefinitely and because interferon (IFN)-α therapy is associated with considerable toxicity. Previously, we showed that linking IFNα to apolipoprotein A-I generates a molecule (IA) with distinct antiviral and immunostimulatory activities which lacks the h...
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The dynamic state of infection of 11 ducks with the duck hepatitis B virus was investigated. Chronic infections were established in newly hatched ducklings by inoculation with a mixture of wild-type virus and a mutant virus with a partial replication defect. As expected, the wild-type virus was rapidly enriched in the virus population during the spread of infection. Enrichment thereafter was co...
متن کاملSerological and molecular evidence of hepadnavirus infection in swine.
INTRODUCTION AND OBJECTIVE Recently, investigations in a swine herd identified evidence of the existence of a novel member of the Hepadnavirus family endemic in swine. The aim of this study was to investigate the serological and molecular markers of Hepadnavirus circulation in Brazilian domestic swine and wild boar herds, and to evaluate the identity with HBV and other Hepadnaviruses reported p...
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ژورنال
عنوان ژورنال: Hepatology International
سال: 2007
ISSN: 1936-0533,1936-0541
DOI: 10.1007/s12072-007-9024-3